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About Novelwise
Pharmaceutical is a biopharmaceutical company dedicated to the discovery and development of a series of histone deacetylase (HDAC) inhibitor programs for oncology and other diseases with high unmet medical needs.
Zhong Yang Huang, Ph.D
Chairman of the Board
Keith Chan, Ph.D
Chief Executive Officer
Tai-Sen Soong, Ph.D
Special Advisor to the Chairman
Metastatic Uveal Melanoma
Mutations in the BAP1 gene prevent normal protection of p53, a key tumor suppressor. At the same time, overexpression of HDAC8 blocks the transcription of p53 protein, allowing cancer cells to grow unchecked. NBM-BMX is a selective HDAC8 inhibitor designed to restore this critical pathway.
Glioblastoma
Mutations in the BAP1 gene prevent normal protection of p53, a key tumor suppressor. At the same time, overexpression of HDAC8 blocks the transcription of p53 protein, allowing cancer cells to grow unchecked. NBM-BMX is a selective HDAC8 inhibitor designed to restore this critical pathway.