Mutations in the BAP1 gene prevent normal protection of p53, a key tumor suppressor. At the same time, overexpression of HDAC8 blocks the transcription of p53 protein, allowing cancer cells to grow unchecked. NBM-BMX is a selective HDAC8 inhibitor designed to restore this critical pathway.

Mutations in the BAP1 gene prevent normal protection of p53, a key tumor suppressor. At the same time, overexpression of HDAC8 blocks the transcription of p53 protein, allowing cancer cells to grow unchecked. NBM-BMX is a selective HDAC8 inhibitor designed to restore this critical pathway.

Hepatocellular Carcinoma：Investigator-Initiated Trial

Mesothelioma：Investigator-Initiated Trial